VX-803 (M4344)

Product Specifications

CAS Number

1613191-99-3

Synonyms

ATR inhibitor 2

Target

ATM/ATR

Applications

PI3K/Akt/mTOR

Smiles

C1CN (CCC1C (=O) N2CCN (CC2) C3COC3) C4=C (C=NC=C4NC (=O) C5=C6N=CC (=CN6N=C5N) F) F

Molecular Formula

C25H29F2N9O3

Additionnal Information

VX-803 (M4344, ATR inhibitor 2) is an ATP-competitive, orally active, and selective inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase with Ki of < 150 pM. VX-803 (M4344) potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (P-Chk1) phosphorylation with IC50 of 8 nM. VX-803 (M4344) exhibits potential antineoplastic activity.