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Donafenib (Sorafenib D3)

Product Specifications

CAS Number

1130115-44-4

Synonyms

Bay 43-9006 D3, CM-4307

Target

Raf

Applications

MAPK

Smiles

CNC (=O) C1=NC=CC (=C1) OC2=CC=C (C=C2) NC (=O) NC3=CC (=C (C=C3) Cl) C (F) (F) F

Molecular Formula

C21H13D3ClF3N4O3

Additionnal Information

Donafenib (Sorafenib D3, Bay 43-9006 D3, CM-4307) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 15 nM, 20 nM and 22 nM for Raf-1, mVEGFR-2, mVEGFR-3 and B-RAF, respectively.

Storage Conditions

3 years -20°C powder

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