Demethylnobiletin
Product Specifications
CAS Number
2174-59-6
Synonyms
5-Demethylnobiletin
Target
Lipoxygenase
Applications
Metabolism
Smiles
COC1=C (C=C (C=C1) C2=CC (=O) C3=C (C (=C (C (=C3O2) OC) OC) OC) O) OC
Molecular Formula
C20H20O8
Additionnal Information
Demethylnobiletin (5-Demethylnobiletin) is a unique flavonoid found in citrus fruits with potential chemopreventive effects against human cancers.5-Demethylnobiletin is a direct inhibitor of 5-LOX with IC50 of 0.1 μM, without affecting the expression of COX-2. 5-Demethylnobiletin has anti-inflammatory activity, inhibits leukotriene B 4 (LTB4) formation in rat neutrophils and elastase release in human neutrophils with IC50 of 0.35 μM.
Storage Conditions
3 years -20°C powder
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