Ginsenoside Rb3

CC (C) =CCCC (C) (OC1OC (COC2OCC (O) C (O) C2O) C (O) C (O) C1O) C3CCC4 (C) C3C (O) CC5C6 (C) CCC (OC7OC (CO) C (O) C (O) C7OC8OC (CO) C (O) C (O) C8O) C (C) (C) C6CCC45C

Ginsenoside Rb3, extracted from the plant Panax ginseng, plays important roles in cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF) -induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL) .