Oroxin B
Product Specifications
CAS Number
114482-86-9
Synonyms
Hypocretin-2
Target
Apoptosis related
Applications
Apoptosis
Smiles
C1=CC=C (C=C1) C2=CC (=O) C3=C (C (=C (C=C3O2) OC4C (C (C (C (O4) COC5C (C (C (C (O5) CO) O) O) O) O) O) O) O) O
Molecular Formula
C27H30O15
Additionnal Information
Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.
Storage Conditions
3 years -20°C powder
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