Homoharringtonine (HHT)
Product Specifications
CAS Number
26833-87-4
Synonyms
CGX-635, Myelostat, NSC 141633
Target
STAT
Applications
Apoptosis
Smiles
CC (C) (CCCC (CC (=O) OC) (C (=O) OC1C2C3=CC4=C (C=C3CCN5C2 (CCC5) C=C1OC) OCO4) O) O
Molecular Formula
C29H39NO9
Additionnal Information
Homoharringtonine (HHT), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.
Storage Conditions
3 years -20°C powder
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