BO-264
Product Specifications
CAS Number
2408648-20-2
Target
TACC3
Applications
Cytoskeletal Signaling
Smiles
COC1=CC=C (C=C1) C2=NOC (=C2) NC3=NC (=NC=C3) N4CCOCC4
Molecular Formula
C18H19N5O3
Additionnal Information
BO-264 is a potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3) with IC50 of 188 nM and Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces SAC-dependent mitotic arrest, apoptosis and DNA damage with antitumor activities.
Storage Conditions
3 years -20°C powder
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