BI-2852
Product Specifications
CAS Number
2375482-51-0
Target
Ras
Applications
Apoptosis
Smiles
CN1C=C (N=C1) CN2C=CC3=C2C=C (C=C3) CNCC4=C (C5=CC=CC=C5N4) C6C7=C (C=CC (=C7) O) C (=O) N6
Molecular Formula
C31H28N6O2
Additionnal Information
BI-2852 is a potent inhibitor of KRAS that binds with nanomolar affinity to a pocket between switch I and II on RAS. BI-2852 blocks all GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in the low micromolar range in KRAS mutant cells.
Storage Conditions
3 years -20°C powder
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
abx659033-01 10 µg
Human DNA Repair Protein Complementing Xp-A Cells (XPA) Protein
Sign In for Pricing
View Details abx659033-02 50 µg
Human DNA Repair Protein Complementing Xp-A Cells (XPA) Protein
Sign In for Pricing
View Details abx659033-03 100 µg
Human DNA Repair Protein Complementing Xp-A Cells (XPA) Protein
Sign In for Pricing
View Details abx659033-04 200 µg
Human DNA Repair Protein Complementing Xp-A Cells (XPA) Protein
Sign In for Pricing
View Details abx659033-05 500 µg
Human DNA Repair Protein Complementing Xp-A Cells (XPA) Protein
Sign In for Pricing
View Details 