KGA-2727
Product Specifications
CAS Number
666842-36-0
Target
SGLT
Applications
GPCR & G Protein
Smiles
CC1=C (C=CC (=C1) OCCCNCCC (=O) N) CC2=C (NN=C2OC3C (C (C (C (O3) CO) O) O) O) C (C) C
Molecular Formula
C26H40N4O8
Additionnal Information
KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat) . KGA-2727 exhibits antidiabetic efficacy in rodent models.
Storage Conditions
3 years -20°C powder
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