TBK1/IKKε-IN-5
Product Specifications
CAS Number
1893397-65-3
Synonyms
Compound 1
Target
IκB/IKK
Applications
NF-κB
Smiles
C1COCCC1OC2=C (C=C (C=C2) C3=NC (=NC=N3) NC4=CC=C (C=C4) N5CCN (CC5) C6COC6) C#N
Molecular Formula
C28H31N7O3
Additionnal Information
TBK1/IKKε-IN-5 (compound 1) is a dual inhibitor of TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε/IKK-i) with IC50 of 1.0 nM and 5.6 nM for TBK1 and IKKε, respectively. TBK1/IKKε inhibition enhances response to PD-1 blockade, which effectively predicts tumor response in vivo.
Storage Conditions
3 years -20°C powder
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
19707121 3x 1.0µg DNA
FAM108B1 CRISPRa sgRNA lentivector (set of three targets)(Human)
Sign In for Pricing
View Details