TBK1/IKKε-IN-5
Product Specifications
CAS Number
1893397-65-3
Synonyms
Compound 1
Target
IκB/IKK
Applications
NF-κB
Smiles
C1COCCC1OC2=C (C=C (C=C2) C3=NC (=NC=N3) NC4=CC=C (C=C4) N5CCN (CC5) C6COC6) C#N
Molecular Formula
C28H31N7O3
Additionnal Information
TBK1/IKKε-IN-5 (compound 1) is a dual inhibitor of TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε/IKK-i) with IC50 of 1.0 nM and 5.6 nM for TBK1 and IKKε, respectively. TBK1/IKKε inhibition enhances response to PD-1 blockade, which effectively predicts tumor response in vivo.
Storage Conditions
3 years -20°C powder
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6307382-01 0.1 mL
HMMR, CT (HMMR, IHABP, RHAMM, Hyaluronan mediated motility receptor, Intracellular hyaluronic acid-binding protein, Receptor for hyaluronan-mediated motility, CD168) (MaxLight 650)
Sign In for Pricing
View Details MBS6307382-02 5x 0.1 mL
HMMR, CT (HMMR, IHABP, RHAMM, Hyaluronan mediated motility receptor, Intracellular hyaluronic acid-binding protein, Receptor for hyaluronan-mediated motility, CD168) (MaxLight 650)
Sign In for Pricing
View Details 