What is the catalog number for TAS0728?

The catalog number for TAS0728 is C13705-5mg.

What sizes are available for TAS0728?

TAS0728 is available in the following size(s): 5 mg.

TAS0728 is currently made to order / not held in immediate stock. Contact us for lead time.

TAS0728

Product Specifications

CAS Number

2088323-16-2

Synonyms

TPC 107

Target

HER2

Applications

Protein Tyrosine Kinase

Smiles

CC1=C (C=CC (=C1C) NC (=O) C2=NN (C3=NC=NC (=C23) N) C4CCCN (C4) C (=O) C=C) CC (=O) N (C) C

Molecular Formula

C26H32N8O3

Additionnal Information

TAS0728 (TPC 107) is a potent, selective, orally active, irreversible and covalent-binding inhibitor of HER2 (human epidermal growth factor receptor 2) with IC50 of 13 nM. TAS0728 inihibits BMX, HER4, BLK, EGFR, JAK3, SLK, LOK and human HER2 with IC50 of 4.9 nM, 8.5 nM, 31 nM, 65 nM, 33 nM, 25 nM, 86 nM and 36 nM, respectively. TAS0728 shows antitumor activity.