Ripretinib

Product Specifications

CAS Number

1442472-39-0

Synonyms

DCC-2618

Target

C-Kit

Applications

Protein Tyrosine Kinase

Smiles

CCN1C2=CC (=NC=C2C=C (C1=O) C3=CC (=C (C=C3Br) F) NC (=O) NC4=CC=CC=C4) NC

Molecular Formula

C24H21BrFN5O2

Additionnal Information

Ripretinib is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of the tumor-associated antigens (TAA) mast/stem cell factor receptor (SCFR) Kit (c-Kit) and PDGFR-alpha, with IC50 values of 4 nM, 8 nM, 18 nM, 5 nM and 14 nM for WT Kit (c-Kit), V654A Kit (c-Kit), T670I Kit (c-Kit), D816H Kit (c-Kit) and D816V Kit (c-Kit), respectively.