Enitociclib (BAY 1251152)

Product Specifications

CAS Number

1610358-56-9

Synonyms

(+) -BAY-1251152

Target

CDK

Applications

Cell Cycle

Smiles

COC1=C (C=CC (=C1) F) C2=CC (=NC=C2F) NC3=NC=CC (=C3) CS (=N) (=O) C

Molecular Formula

C19H18F2N4O2S

Additionnal Information

Enitociclib (BAY 1251152) is a potent PTEFb/CDK9 inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins.