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Atuveciclib (BAY-1143572)

Product Specifications

CAS Number

1414943-88-6

Target

CDK

Applications

Cell Cycle

Smiles

COC1=C (C=CC (=C1) F) C2=NC (=NC=N2) NC3=CC=CC (=C3) CS (=N) (=O) C

Molecular Formula

C18H18FN5O2S

Additionnal Information

Atuveciclib (BAY-1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with IC50 values of 13 nM for CDK9/CycT and the ratio of IC50 values for CDK2/CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β respectively.

Storage Conditions

3 years -20°C powder

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