Atuveciclib (BAY-1143572)
Product Specifications
CAS Number
1414943-88-6
Target
CDK
Applications
Cell Cycle
Smiles
COC1=C (C=CC (=C1) F) C2=NC (=NC=N2) NC3=CC=CC (=C3) CS (=N) (=O) C
Molecular Formula
C18H18FN5O2S
Additionnal Information
Atuveciclib (BAY-1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with IC50 values of 13 nM for CDK9/CycT and the ratio of IC50 values for CDK2/CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β respectively.
Storage Conditions
3 years -20°C powder
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