Lazertinib
Product Specifications
CAS Number
1903008-80-9
Synonyms
YH25448, GNS-1480
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
CN (C) CC1=CN (N=C1C2=CC=CC=C2) C3=NC (=NC=C3) NC4=C (C=C (C (=C4) NC (=O) C=C) N5CCOCC5) OC
Molecular Formula
C30H34N8O3
Additionnal Information
Lazertinib (YH25448, GNS-1480) is a potent, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild type EGFR respectively, showing much higher IC50 values aganist ErbB2 and ErbB4.
Storage Conditions
3 years -20°C powder
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