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MK-8353 (SCH900353)

Product Specifications

CAS Number

1184173-73-6

Target

ERK

Applications

MAPK

Smiles

CC (C) OC1=NC=C (C=C1) C2=NNC3=C2C=C (C=C3) NC (=O) C4 (CCN (C4) CC (=O) N5CCC (=CC5) C6=CC=C (C=C6) C7=NN (C=N7) C) SC

Molecular Formula

C37H41N9O3S

Additionnal Information

MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay) .

Storage Conditions

3 years -20°C powder

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