MK-8353 (SCH900353)
Product Specifications
CAS Number
1184173-73-6
Target
ERK
Applications
MAPK
Smiles
CC (C) OC1=NC=C (C=C1) C2=NNC3=C2C=C (C=C3) NC (=O) C4 (CCN (C4) CC (=O) N5CCC (=CC5) C6=CC=C (C=C6) C7=NN (C=N7) C) SC
Molecular Formula
C37H41N9O3S
Additionnal Information
MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay) .
Storage Conditions
3 years -20°C powder
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