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TP0427736 HCl

Product Specifications

CAS Number

864374-00-5

Target

TGF-beta/Smad

Applications

TGF-beta/Smad

Smiles

CC1=CSC (=N1) C2=C (N=CN2) C3=CC4=C (C=C3) N=CS4

Molecular Formula

C14H11ClN4S2

Additionnal Information

TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3) . It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.

Storage Conditions

3 years -20°C powder

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