What is the catalog number for RAF709?

The catalog number for RAF709 is C18211-25mg.

What sizes are available for RAF709?

RAF709 is available in the following size(s): 25 mg.

RAF709 is currently made to order / not held in immediate stock. Contact us for lead time.

Are there any special shipping requirements for RAF709?

RAF709 is requires dry ice shipping.

RAF709

Product Specifications

CAS Number

1628838-42-5

Target

Raf

Applications

MAPK

Smiles

CC1=C (C=C (C=N1) NC (=O) C2=CC (=CC=C2) C (F) (F) F) C3=CC (=C (N=C3) OC4CCOCC4) N5CCOCC5

Molecular Formula

C28H29F3N4O4

Additionnal Information

RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.4 nM for B-RAF and C-RAF, showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF, BRAFV600E, and CRAF at 1 μM and very few off-targets with DDR1 (>99%), DDR2 (86%), FRK (92%), and PDGFRb (96%), the only kinases with binding >80% at 1 μM.