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MPP dihydrochloride

Product Specifications

CAS Number

911295-24-4

Synonyms

Methylpiperidino pyrazole

Target

Estrogen/progestogen Receptor

Applications

Endocrinology & Hormones

Molecular Formula

C29H31N3O3.2ClH

Additionnal Information

Methyl-piperidino-pyrazole (MPP) dihydrochloride is a highly selective antagonist for estrogen receptor alpha (ERα), with an affinity 200 times greater than for estrogen receptor beta (ERβ) . It inhibits 17β-estradiol binding to ERα by inducing conformational changes that alter the receptor’s binding site and also increases the energy required for genistein's interaction with ERα.

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