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Tolinapant (ASTX660)

Product Specifications

CAS Number

1799328-86-1

Target

IAP

Applications

Apoptosis

Smiles

CC1CN (C (CN1) CN2CCOCC2C) CC (=O) N3CC (C4=C3C=C (C (=N4) CO) CC5=CC=C (C=C5) F) (C) C

Molecular Formula

C30H42FN5O3

Additionnal Information

Tolinapant (ASTX660) is a potent, non-peptidomimetic antagonist of cIAP1/2 and XIAP that inhibits the interactions between a SMAC-derived peptide and the BIR3 domains of XIAP (BIR3-XIAP) and cIAP1 (BIR3-cIAP1) with IC50 values less than 40 and 12 nmol/L, respectively.

Storage Conditions

3 years -20°C powder

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