H3B-6527
Product Specifications
CAS Number
1702259-66-2
Target
FGFR
Applications
Protein Tyrosine Kinase
Smiles
CCN1CCN (CC1) C2=CC (=C (C=C2) NC3=CC (=NC=N3) N (C) C (=O) NC4=C (C (=CC (=C4Cl) OC) OC) Cl) NC (=O) C=C
Molecular Formula
C29H34Cl2N8O4
Additionnal Information
H3B-6527 is a highly selective covalent FGFR4 inhibitor with an IC50 value of <1.2 nM and at least 250-fold selectivity over FGFR1-3 (IC50 values of 320, 1,290 and 1,060 nM respectively) .
Storage Conditions
2 years -80 in solvent
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