BML-277 (Chk2 Inhibitor II)
Product Specifications
CAS Number
516480-79-8
Target
Chk
Applications
Cell Cycle
Smiles
C1=CC (=CC=C1C2=NC3=C (N2) C=C (C=C3) C (=O) N) OC4=CC=C (C=C4) Cl
Molecular Formula
C20H14ClN3O2
Additionnal Information
BML-277 (Chk2 Inhibitor II) is an ATP-competitive inhibitor of Chk2 with IC50 of 15 nM. It is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases. Chk2 Inhibitor II (BML-277) dose dependently protects human CD4 (+) and CD8 (+) T-cells from apoptosis due to ionizing radiation.
Storage Conditions
2 years -80 in solvent
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