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Onametostat (JNJ-64619178)

Product Specifications

CAS Number

2086772-26-9

Target

Histone Methyltransferase

Applications

Epigenetics

Smiles

C1C (C (C (C1N2C=CC3=C (N=CN=C32) N) O) O) CCC4=CC5=NC (=C (C=C5C=C4) Br) N

Molecular Formula

C22H23BrN6O2

Additionnal Information

Onametostat (JNJ-64619178) is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.

Storage Conditions

2 years -80 in solvent

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