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Siremadlin (HDM201)

Product Specifications

CAS Number

1448867-41-1

Synonyms

NVP-HDM201

Target

MDM2/MDMX

Applications

Apoptosis

Smiles

CC (C) N1C2=C (C (=O) N (C2C3=CC=C (C=C3) Cl) C4=CC (=CN (C4=O) C) Cl) N=C1C5=CN=C (N=C5OC) OC

Molecular Formula

C26H24Cl2N6O4

Additionnal Information

Siremadlin (HDM201) is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4.

Storage Conditions

2 years -80 in solvent

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