LYN-1604
Product Specifications
CAS Number
2088939-99-3
Target
Autophagy
Applications
Autophagy
Smiles
CC (C) CN (CC (C) C) CC (=O) N1CCN (CC1) CC (C2=C (C=C (C=C2) Cl) Cl) OCC3=CC4=CC=CC=C4C=C3
Molecular Formula
C33H45Cl4N3O2
Additionnal Information
LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM) . The ULK1 (Y89A) mutant protein caused a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1 (K50A) and ULK1 (L53A) mutants.
Storage Conditions
2 years -80 in solvent
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