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LYN-1604

Product Specifications

CAS Number

2088939-99-3

Target

Autophagy

Applications

Autophagy

Smiles

CC (C) CN (CC (C) C) CC (=O) N1CCN (CC1) CC (C2=C (C=C (C=C2) Cl) Cl) OCC3=CC4=CC=CC=C4C=C3

Molecular Formula

C33H45Cl4N3O2

Additionnal Information

LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM) . The ULK1 (Y89A) mutant protein caused a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1 (K50A) and ULK1 (L53A) mutants.

Storage Conditions

2 years -80 in solvent

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