VX-984
Product Specifications
CAS Number
1476074-39-1
Synonyms
M9831
Target
DNA-PK
Applications
PI3K/Akt/mTOR
Molecular Formula
C23H21D2N7O
Additionnal Information
VX-984 (M9831) is an orally active, potent, selective, and ATP-competitive inhibitor of DNA-PK. VX-984 effectively suppresses non-homologous end joining (NHEJ) and increases DNA double-strand breaks (DSBs) . It enhances the cytotoxic effects of ionizing radiation (IR) in various cancer cell lines, including non-small cell lung cancer (NSCLC) cell lines, in vitro. Additionally, VX-984 reduces DNA-PKcs autophosphorylation.
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