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Withaferin A (WFA)

Product Specifications

CAS Number

5119-48-2

Synonyms

WA

Target

NF-κB

Applications

NF-κB

Molecular Formula

C28H38O6

Additionnal Information

Withaferin A (WFA) potently inhibits NF-κB activation by preventing the tumor necrosis factor-induced activation of IκB kinase β via a thioalkylation-sensitive redox mechanism. Withaferin A binds to the intermediate filament (IF) protein, vimentin with antitumor and antiangiogenesis activity. Withaferin A is a steroidal lactone isolated from Withania somnifera.

Storage Conditions

3 years -20°C powder

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