Theliatinib (HMPL-309)
Product Specifications
CAS Number
1353644-70-8
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
COC1=C (NC (=O) N2CC3CCN (C) C3C2) C=C4C (=NC=NC4=C1) NC5=CC (=CC=C5) C#C
Molecular Formula
C25H26N6O2
Additionnal Information
Theliatinib (HMPL-309) is a highly potent EGFR inhibitor with Ki value of 0.05 nM against the wild type EGFR and IC50 values of 3 nM and 22 nM against EGFR and EGFR T790M/L858R mutant. It demonstrats 50 fold greater selectivity for EGFR compared to 72 other kinases.
Storage Conditions
3 years -20°C powder
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