Avapritinib (BLU-285)
Product Specifications
CAS Number
1703793-34-3
Synonyms
BLU-285
Target
PDGFR
Applications
Protein Tyrosine Kinase
Smiles
CC (C1=CC=C (C=C1) F) (C2=CN=C (N=C2) N3CCN (CC3) C4=NC=NN5C4=CC (=C5) C6=CN (N=C6) C) N
Molecular Formula
C26H27FN10
Additionnal Information
Avapritinib is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM) ; also a potent inhibitor of the analogous Kit (c-Kit) mutation, D816V in Kit (c-Kit) Exon 17 (IC50 = 0.5 nM) .
Storage Conditions
2 years -80 in solvent
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