CBL0137 HCl
Product Specifications
CAS Number
1197397-89-9
Synonyms
CBLC137 HCl, Curaxin 137 HCl
Target
P53
Applications
Apoptosis
Smiles
CC (C) NCCN1C2=C (C=C (C=C2) C (=O) C) C3=C1C=CC (=C3) C (=O) C.Cl
Molecular Formula
C21H24N2O2.HCl
Additionnal Information
CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-κB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex) .
Storage Conditions
2 years -80 in solvent
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