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CAY10585 (LW 6)

Product Specifications

CAS Number

934593-90-5

Synonyms

AC1-001

Target

HIF

Applications

Angiogenesis

Smiles

COC (=O) C1=CC (=C (C=C1) O) NC (=O) COC2=CC=C (C=C2) C34CC5CC (C3) CC (C5) C4

Molecular Formula

C26H29NO5

Additionnal Information

CAY10585 (LW 6) is a hypoxia-inducible factor 1 (HIF) inhibitor which potently inhibits HIF-1α accumulation by degrading HIF-1α without affecting the HIF-1a mRNA levels during hypoxia. LW6 inhibits HIF and MDH2 expression with IC50 values of 4.4 and 6.3 μM, respectively.

Storage Conditions

2 years -80 in solvent

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