Stenoparib (E7449)
Product Specifications
CAS Number
1140964-99-3
Synonyms
2X-121, MGI25036
Target
PARP
Applications
DNA Damage/DNA Repair
Smiles
C1C2=CC=CC=C2CN1CC3=NC4=NNC (=O) C5=C4C (=CC=C5) N3
Molecular Formula
C18H15N5O
Additionnal Information
Stenoparib (E7449, 2X-121, MGI25036) is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 and also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.
Storage Conditions
2 years -80 in solvent
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