Mivebresib (ABBV-075)
Product Specifications
CAS Number
1445993-26-9
Target
Epigenetic Reader Domain
Applications
Epigenetics
Smiles
CCS (=O) (=O) NC1=CC (=C (C=C1) OC2=C (C=C (C=C2) F) F) C3=CN (C (=O) C4=C3C=CN4) C
Molecular Formula
C22H19F2N3O4S
Additionnal Information
Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4) . Mivebresib (ABBV-075) efficiently triggers apoptosis in various tumor cell.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
KN401334 1 Kit
PP2A-alpha (PPP2CA) Human Gene Knockout Kit (CRISPR)
Sign In for Pricing
View Details 
ICH1049-100mg 100 mg
Anti-Mouse CD11b (M1/70) In Vivo Antibody - Low Endotoxin
Sign In for Pricing
View Details 
![GLI4 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3D5]](https://cdn.genprice.uk/products/937/68dd1b7d061270361ea1ce56/imageurl/ta806083am.webp)
TA806083AM 100 µL
GLI4 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3D5]
Sign In for Pricing
View Details 
BNC472316-500 1x 500 µL
Cdk2 / p34cdc2 Serine-Threonine Kinase (AN4.3), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details