BMS-986142
Product Specifications
CAS Number
1643368-58-4
Target
BTK
Applications
Protein Tyrosine Kinase
Smiles
CC1=C (C=CC=C1N2C (=O) C3=C (C (=CC=C3) F) N (C2=O) C) C4=C (C=C (C5=C4C6=C (N5) CC (CC6) C (C) (C) O) C (=O) N) F
Molecular Formula
C32H30F2N4O4
Additionnal Information
BMS-986142 is a potent and highly selective reversible small molecule inhibitor of BTK with an IC50 of 0.5 nM. In a panel of 384 kinases, only five kinases were inhibited by BMS-986142 with less than 100-fold selectivity for BTK (TEC, ITK, BLK, TXK and BMX) .
Storage Conditions
3 years -20°C powder
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