NMS-P118
Product Specifications
CAS Number
1262417-51-5
Target
PARP
Applications
DNA Damage/DNA Repair
Smiles
C1CC (CCC1N2CCC (CC2) N3CC4=C (C3=O) C (=CC (=C4) F) C (=O) N) (F) F
Molecular Formula
C20H24F3N3O2
Additionnal Information
NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively) .
Storage Conditions
2 years -80 in solvent
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