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BMS-935177

Product Specifications

CAS Number

1231889-53-4

Target

BTK

Applications

Protein Tyrosine Kinase

Smiles

CC1=C (C=CC=C1N2C=NC3=CC=CC=C3C2=O) C4=C5C6=C (C=C (C=C6) C (C) (C) O) NC5=C (C=C4) C (=O) N

Molecular Formula

C31H26N4O3

Additionnal Information

BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.

Storage Conditions

2 years -80 in solvent

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