What is the catalog number for TAK-243 (MLN7243)?

The catalog number for TAK-243 (MLN7243) is C13356-2mg.

What sizes are available for TAK-243 (MLN7243)?

TAK-243 (MLN7243) is available in the following size(s): 2 mg.

Is TAK-243 (MLN7243) in stock?

TAK-243 (MLN7243) is currently made to order / not held in immediate stock. Contact us for lead time.

TAK-243 (MLN7243)

Product Specifications

CAS Number

1450833-55-2

Target

E1 Activating

Applications

Ubiquitin

Smiles

N[S; v6] (=O) (=O) OCC1CC (NC2=CC=NC3=CC (=N[N]23) C4=CC (=CC=C4) SC (F) (F) F) C (O) C1O

Molecular Formula

C19H20F3N5O5S2

Additionnal Information

TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and receptor assays, as well as on human carbonic anhydrase type I and type II. TAK-243 (MLN7243) induces ER stress, abrogates NFκB pathway activation and promotes apoptosis.