DBET1
Product Specifications
CAS Number
1799711-21-9
Target
Epigenetic Reader Domain
Applications
Epigenetics
Smiles
CC1=C (SC2=C1C (=NC (C3=NN=C (N32) C) CC (=O) NCCCCNC (=O) COC4=CC=CC5=C4C (=O) N (C5=O) C6CCC (=O) NC6=O) C7=CC=C (C=C7) Cl) C
Molecular Formula
C38H37ClN8O7S
Additionnal Information
DBET1 is a CRBN-based BET degrader with an IC50 of 20 nM, showing highly selectivity. Out of 7,429 proteins, only the expression of the oncoproteins MYC and PIM1, as well as BRD2, BRD3 and BRD4 are significantly downregulated by dBET1 treatment.
Storage Conditions
3 years -20°C powder
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