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Tomivosertib (eFT-508)

Product Specifications

CAS Number

1849590-01-7

Target

MNK

Applications

MAPK

Smiles

CC1=C2C (=O) NC3 (N2C (=O) C (=C1) NC4=NC=NC (=C4) N) CCCCC3

Molecular Formula

C17H20N6O2

Additionnal Information

Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.

Storage Conditions

2 years -80 in solvent

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