APTSTAT3-9R

CC (C) CC (NC (=O) C (CC1=CC=CC=C1) NC (=O) C (CCC (N) =O) NC (=O) C (CC2=CC=C (O) C=C2) NC (=O) C (C) NC (=O) CNC (=O) C (CCCCN) NC (=O) C (CC3=C[NH]C4=CC=CC=C34) NC (=O) C (NC (=O) C (CC5=C[NH]C6=CC=CC=C56) NC (=O) C (CCCCN) NC (=O) CNC (=O) C (CC (N) =O) NC (=O) C (CCC (O) =O) NC (=O) C (CC7=C[NH]C8=CC=CC=C78) NC (=O) C (NC (=O) C (CC9=C[NH]C%10=CC=CC=C9%10) NC (=O) C (CO) NC (=O) CNC (=O) C%11CCCN%11C (=O) C (CC%12=C[NH]C%13=CC=CC=C%12%13) NC (=O) C (CCC (N) =O) NC (=O) C (CC%14=CC=CC=C%14) NC (=O) CNC (=O) C (N) CC%15=C[NH]C=N%15) C (C) O) C (C) O) C (=O) NC (CCCCN) C (=O) NCC (=O) NCC (=O) NCC (=O) NCC (=O) NC (CO) C (=O) NC (CCCNC (N) =N) C (=O) NC (CCCNC (N) =N) C (=O) NC (CCCNC (N) =N) C (=O) NC (CCCNC (N) =N) C (=O) NC (CCCNC (N) =N) C (=O) NC (CCCNC (N) =N) C (=O) NC (CCCNC (N) =N) C (=O) NC (CCCNC (N) =N) C (=O) NC (CCCNC (N) =N) C (O) =O

APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets.