Paxalisib (GDC-0084)
Product Specifications
CAS Number
1382979-44-3
Synonyms
RG7666
Target
PI3K
Applications
PI3K/Akt/mTOR
Smiles
CC1 (C2=NC3=C (N2CCO1) N=C (N=C3N4CCOCC4) C5=CN=C (N=C5) N) C
Molecular Formula
C18H22N8O2
Additionnal Information
Paxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.
Storage Conditions
2 years -80 in solvent
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