Plicamycin
Product Specifications
CAS Number
18378-89-7
Synonyms
Mithramycin A
Target
Others
Applications
Others
Smiles
CC1C (C (CC (O1) OC2CC (OC (C2O) C) OC3=CC4=CC5=C (C (=O) C (C (C5) C (C (=O) C (C (C) O) O) OC) OC6CC (C (C (O6) C) O) OC7CC (C (C (O7) C) O) OC8CC (C (C (O8) C) O) (C) O) C (=C4C (=C3C) O) O) O) O
Molecular Formula
C52H76O24
Additionnal Information
Plicamycin (Mithramycin A) a selective inhibitor of Sp1, is a natural polycyclic aromatic polyketide isolated from Streptomyces strains. It binds to GC-rich DNA sequences, displacing Sp1 transcription factor from oncogene promoters, inhibiting their expression, with anti-tumor and neuroprotective effects.
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