GANT61
Product Specifications
CAS Number
500579-04-4
Synonyms
NSC 136476
Target
Hedgehog/Smoothened
Applications
Stem Cells & Wnt
Smiles
CN (C) C1=CC=CC=C1CN2CCCN (C2C3=CC=NC=C3) CC4=CC=CC=C4N (C) C
Molecular Formula
C27H35N5
Additionnal Information
GANT61 (NSC 136476) is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM in GLI1 expressing HEK293T cell, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. GANT61 induces apoptosis and activates protective autophagy in LX-2 cells.
Storage Conditions
2 years -80 in solvent
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