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Necrostatin-1

Product Specifications

CAS Number

4311-88-0

Synonyms

Nec-1

Target

TNF-alpha

Applications

Apoptosis

Smiles

CN1C (=O) C (NC1=S) CC2=CNC3=CC=CC=C32

Molecular Formula

C13H13N3OS

Additionnal Information

Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.

Storage Conditions

2 years -80 in solvent

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