Tyrphostin AG 1296

Product Specifications

CAS Number

146535-11-7

Synonyms

AG 1296

Target

C-Kit

Applications

Protein Tyrosine Kinase

Smiles

COC1=C (C=C2C (=C1) N=CC (=N2) C3=CC=CC=C3) OC

Molecular Formula

C16H14N2O2

Additionnal Information

Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. Tyrphostin AG1296 inhibits FGFR and c-Kit with IC50 of 12.3 μM and 1.8 μM in Swiss 3T3 cells. Tyrphostin AG1296 induces dramatic apoptosis in A375R cells.

Storage Conditions

2 years -80 in solvent

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