Ricolinostat (ACY-1215)
Product Specifications
CAS Number
1316214-52-4
Synonyms
Rocilinostat
Target
HDAC
Applications
DNA Damage/DNA Repair
Smiles
C1=CC=C (C=C1) N (C2=CC=CC=C2) C3=NC=C (C=N3) C (=O) NCCCCCCC (=O) NO
Molecular Formula
C24H27N5O3
Additionnal Information
Ricolinostat (ACY-1215, Rocilinostat) is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2. Ricolinostat (ACY-1215) suppresses cell proliferation and promotes apoptosis. Phase 2.
Storage Conditions
2 years -80 in solvent
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